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ERG (DGR14749) Rabbit mAb (PBS Only)
db15239-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
- Immunogen A synthetic peptide of human ERG
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Gene ID
2078
-
Swiss Prot
P11308
- Synonyms p55; erg-3
- Reactivity Human,Mouse
- Application WB, IHC-P, ICC/IF, FC, IP
- Calculated MW 55 kDa
- Observed MW 55 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR14749
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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订购信息
- Package Price (RMB)
- 10μg 1498
- 100μg 4498
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
