CD31 (DGR14419) Rabbit mAb (PBS Only)
Product Name :
CD31 (DGR14419) Rabbit mAb (PBS Only)
Cat.No.:
db15307-PBS
Synonyms :
Cd31; Pecam; C85791; PECAM-1
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore.
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Immunogen
Recombinant protein of mouse CD31
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Gene ID
18613
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Swiss Prot
Q08481
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Synonyms
Cd31; Pecam; C85791; PECAM-1
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Reactivity
Human,Mouse,Rat
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Application
IHC-P
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Recommended dilution
IHC-P: 1:200-1:2000
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Calculated MW
83 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR14419
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/ml
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
5798
- 货期：现货
For research use only. Not intended for diagnostic.
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