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Caspase-8 (DGR12682) Rabbit mAb (PBS Only)
db15744-PBS
Datasheet
Product Name : Caspase-8 (DGR12682) Rabbit mAb (PBS Only)
Cat.No.: db15744-PBS
Synonyms : CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Application：
Reactivity : Human
Host species : Rabbit
Conjugation/Formulation：PBS Only
- Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human Caspase-8
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Gene ID
841
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Swiss Prot
Q14790
- Synonyms CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
- Reactivity Human
- Application WB
- Recommended dilution WB: 1:1000
- Calculated MW 55 kDa
- Observed MW 55 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12682
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from Jurkat cells using db15744
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
