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Dnmt1 (DGR12018) Rabbit mAb (PBS Only)
db15843-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- Immunogen A synthetic peptide of human Dnmt1
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Gene ID
1786
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Swiss Prot
P26358
- Synonyms AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC
- Calculated MW 183 kDa
- Observed MW 183 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12018
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Immunofluorescence analysis of HeLa cells labelling Dnmt1 with db15843.
The cells were fixed with 4% PFA (10min, RT) followed by treatment with 0.1% Triton X-100 (10min, RT), and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db15843 (1:200) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.
Control: Secondary antibody only.
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- Package Price (RMB)
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- 货期：现货
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For research use only. Not intended for diagnostic.
