DUT (DGR36094) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

DUT (DGR36094) Rabbit mAb

db16329

Datasheet

Product Name : DUT (DGR36094) Rabbit mAb

Cat.No.: db16329

Synonyms : BMFDMS; dUTPase

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of Human DUT
Gene ID 1854
Swiss Prot P33316
Synonyms BMFDMS; dUTPase
Reactivity Human
Application WB, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:10000
ICC/IF: 1:200-1:1000
FC: 1:200-1:1000
IP: 1:100-1:200
Calculated MW 27 kDa
Observed MW 19 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR36094
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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