HLA-DRB4 (DGR36129) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

HLA-DRB4 (DGR36129) Rabbit mAb

db16364

Datasheet

Product Name : HLA-DRB4 (DGR36129) Rabbit mAb

Cat.No.: db16364

Synonyms : DR4; DRB4; HLA-DRB; HLA-DR4B; HLA-DRB4*

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]
Immunogen A synthetic peptide of Human HLA-DRB4
Gene ID 3126
Swiss Prot P13762
Synonyms DR4; DRB4; HLA-DRB; HLA-DR4B; HLA-DRB4*
Reactivity Human
Application WB, IHC-P
Recommended dilution WB: 1:1000
IHC-P: 1:100-1:200
Calculated MW 30 kDa
Observed MW 30 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR36129
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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