MAP3K3 (DGR36164) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

MAP3K3 (DGR36164) Rabbit mAb

db16399

年底大促

Datasheet

Product Name : MAP3K3 (DGR36164) Rabbit mAb

Cat.No.: db16399

Synonyms : CCM5; MEKK3; MAPKKK3

Application：

Reactivity : Human, Mouse

Host species : Rabbit

Un-conjugated

Background This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human MEKK3
Gene ID 4215
Swiss Prot Q99759
Synonyms CCM5; MEKK3; MAPKKK3
Reactivity Human, Mouse
Application WB, IHC-P, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC-P: 1:50
ICC/IF: 1:100
FC: 1:100-1:500
IP: 1:20
Calculated MW 71 kDa
Observed MW 71 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR36164
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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