Phospho-ErbB 3 (Tyr1289) Rabbit pAb
Product Name :
Phospho-ErbB 3 (Tyr1289) Rabbit pAb
Cat.No.:
db1845
Synonyms :
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
-
Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
-
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding
Tyr1289 of human ErbB 3
-
Gene ID
2065
-
Swiss Prot
P21860
-
Synonyms
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
-
Reactivity
Human
-
Application
WB, ICC/IF
-
Recommended dilution
WB: 1:1000
ICC/IF: 1:20
-
Calculated MW
148 kDa
-
Observed MW
185 kDa
-
Host species
Rabbit
-
Clonality
Polyclonal
-
Isotype
IgG
-
Purity
Affinity Purification
-
Conjugation
Un-conjugated
-
Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
-
Package
Price (RMB)
-
20μL
698
-
50μL
1398
-
100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
浙公网安备 33010602008812号