LIM kinase 2 Rabbit pAb - diagbio | 戴格生物

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LIM kinase 2 Rabbit pAb

db1867

年底大促

Datasheet

Product Name : LIM kinase 2 Rabbit pAb

Cat.No.: db1867

Synonyms : LIMK2

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human LIM kinase 2
Gene ID 3985
Swiss Prot P53671
Synonyms LIMK2
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC: 1:20
ICC/IF: 1:20-1:50
FC: 1:20
IP: 1:20
Calculated MW 72 kDa
Observed MW 72 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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