Bcr Rabbit pAb - diagbio | 戴格生物

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Bcr Rabbit pAb

db20007

年底大促

Datasheet

Product Name : Bcr Rabbit pAb

Cat.No.: db20007

Synonyms : ALL; CML; PHL; BCR1; D22S11; D22S662

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
Immunogen A synthetic peptide of human Bcr
Gene ID 613
Swiss Prot P11274
Synonyms ALL; CML; PHL; BCR1; D22S11; D22S662
Reactivity Human
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:2000
IHC: 1:20
ICC/IF: 1:50
FC: 1:20
IP: 1:20
Calculated MW 143 kDa
Observed MW 160 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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