Angiotensin II Type 2 Receptor Rabbit pAb
Product Name :
Angiotensin II Type 2 Receptor Rabbit pAb
Cat.No.:
db20411
Synonyms :
AT2; ATGR2; MRX88
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
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Background
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection result in down-regulation of ACE2 (angiotensin converting enzyme-2) receptors which triggers serious inflammatory lesions, primarily in the lungs. The inflammatory reaction is mediated by angiotensin II derivatives; however, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of ARDS (acute respiratory distress syndrome), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. [provided by RefSeq, Jun 2020]
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Immunogen
A synthetic peptide of human Angiotensin II Type 2 Receptor
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Gene ID
186
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Swiss Prot
P50052
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Synonyms
AT2; ATGR2; MRX88
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Reactivity
Human, Mouse, Rat
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Application
WB, IP
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Recommended dilution
WB: 1:1000
IP: 1:20
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Calculated MW
41 kDa
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Observed MW
41 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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