Nicotinic Acetylcholine Receptor alpha 4 Rabbit pAb - diagbio

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Nicotinic Acetylcholine Receptor alpha 4 Rabbit pAb

db20481

Datasheet

Product Name : Nicotinic Acetylcholine Receptor alpha 4 Rabbit pAb

Cat.No.: db20481

Synonyms : EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4

Application : WB, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Immunogen A synthetic peptide of human Nicotinic Acetylcholine Receptor alpha 4/CHRNA4
Gene ID 1137
Swiss Prot P43681
Synonyms EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
Reactivity Human, Mouse, Rat
Application WB, ICC/IF, IP
Recommended dilution WB: 1:2000-1:10000
ICC/IF: 1:20
IP: 1:20
Calculated MW 70 kDa
Observed MW 70 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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