MEK2 Rabbit pAb - diagbio | 戴格生物

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MEK2 Rabbit pAb

db20554

年底大促

Datasheet

Product Name : MEK2 Rabbit pAb

Cat.No.: db20554

Synonyms : CFC4; MEK2; MKK2; MAPKK2; PRKMK2

Application：

Reactivity : Human, Mouse

Host species : Rabbit

Un-conjugated

Background The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human MEK2
Gene ID 5605
Swiss Prot P36507
Synonyms CFC4; MEK2; MKK2; MAPKK2; PRKMK2
Reactivity Human, Mouse
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:2000
IHC: 1:20
ICC/IF: 1:20
FC: 1:20
IP: 1:20
Calculated MW 43 kDa
Observed MW 43 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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