Phospho-Rad17 (Ser656) Rabbit pAb
Product Name :
Phospho-Rad17 (Ser656) Rabbit pAb
Cat.No.:
db20959
Synonyms :
CCYC; R24L; RAD24; HRAD17; RAD17SP
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
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Background
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser656 of human Rad17
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Gene ID
5884
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Swiss Prot
O75943
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Synonyms
CCYC; R24L; RAD24; HRAD17; RAD17SP
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Reactivity
Human
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Application
WB, IHC, ICC/IF
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Recommended dilution
WB: 1:1000-1:5000
IHC: 1:501:50
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Calculated MW
77 kDa
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Observed MW
80 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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