Product Name :
NCF4 Rabbit pAb
Cat.No.:
db21003
Synonyms :
NCF; CGD3; P40PHOX; SH3PXD4
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
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Background
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic peptide of human p40-phox
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Gene ID
4689
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Swiss Prot
Q15080
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Synonyms
NCF; CGD3; P40PHOX; SH3PXD4
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Reactivity
Human
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Application
WB, IHC, ICC/IF, FC, IP
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Recommended dilution
WB: 1:2000-1:10000
IHC: 1:50
ICC/IF: 1:50
FC: 1:20
IP: 1:20
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Calculated MW
39 kDa
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Observed MW
40 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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