MC1-R Rabbit pAb - diagbio | 戴格生物

产品中心 Products Center

您当前的位置：

MC1-R Rabbit pAb

db21190

年底大促

Datasheet

Product Name : MC1-R Rabbit pAb

Cat.No.: db21190

Synonyms : CMM5; MSH-R; SHEP2

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human MC1-R
Gene ID 4157
Swiss Prot Q01726
Synonyms CMM5; MSH-R; SHEP2
Reactivity Human
Application WB, IHC
Recommended dilution WB: 1:1000
IHC: 1:200
Calculated MW 35 kDa
Observed MW 35 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

订购信息