Phospho-Topoisomerase II alpha (Thr1343) Rabbit pAb
Product Name :
Phospho-Topoisomerase II alpha (Thr1343) Rabbit pAb
Cat.No.:
db21219
Synonyms :
TOP2; TP2A
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
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Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Thr1343 of human Topoisomerase II alpha
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Gene ID
7153
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Swiss Prot
P11388
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Synonyms
TOP2; TP2A
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Reactivity
Human
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Application
WB, IHC, ICC/IF
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Recommended dilution
WB: 1:1000
IHC: 1:20
ICC/IF: 1:20
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Calculated MW
174 kDa
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Observed MW
174 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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