Phospho-CBL (Tyr731) Rabbit pAb - diagbio | 戴格生物

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Phospho-CBL (Tyr731) Rabbit pAb

db22254

年底大促

Datasheet

Product Name : Phospho-CBL (Tyr731) Rabbit pAb

Cat.No.: db22254

Synonyms : CBL2; NSLL; C-CBL; RNF55; FRA11B

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr731 of human CBL
Gene ID 867
Swiss Prot P22681
Synonyms CBL2; NSLL; C-CBL; RNF55; FRA11B
Reactivity Human, Mouse, Rat
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 100 kDa
Observed MW 120 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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