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Product Name : TPOR Rabbit pAb
Cat.No.: db2263
Synonyms : MPLV; TPOR; C-MPL; CD110; THCYT2
Application：
Reactivity : Human, Mouse, Rat
Host species : Rabbit
Conjugation/Formulation：Un-conjugated
- Background In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human TPOR
-
Gene ID
4352
-
Swiss Prot
P40238
- Synonyms MPLV; TPOR; C-MPL; CD110; THCYT2
- Reactivity Human, Mouse, Rat
- Application WB
- Recommended dilution WB: 1:1000-1:5000
- Calculated MW 71 kDa
- Observed MW 85 kDa
- Host species Rabbit
- Clonality Polyclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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订购信息
- Package Price (RMB)
- 20μL 598
- 50μL 998
- 100μL 1798
- 货期：现货
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For research use only. Not intended for diagnostic.
