MLKL单克隆抗体(DGR33761) | 高特异性&高亲和力

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MLKL (DGR33761) Rat mAb (PBS Only)

db22650-PBS

Datasheet

Product Name : MLKL (DGR33761) Rat mAb (PBS Only)

Cat.No.: db22650-PBS

Synonyms : hMLKL

Application：

Reactivity : Human, Mouse, Rat

Host species : Rat

Un-conjugated PBS Only

Background This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Immunogen A synthetic peptide of human MLKL
Gene ID 197259
Swiss Prot Q9D2Y4
Synonyms hMLKL
Reactivity Human, Mouse, Rat
Application WB
Calculated MW 54 kDa
Observed MW 54 kDa
Host species Rat
Clonality Monoclonal
Clonality No. DGR33761
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

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