FEN1 Rabbit pAb - diagbio | 戴格生物

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FEN1 Rabbit pAb

db2339

年底大促

Datasheet

Product Name : FEN1 Rabbit pAb

Cat.No.: db2339

Synonyms : MF1; RAD2; FEN-1

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated Un-conjugated

Background The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human FEN1
Gene ID 2237
Swiss Prot P39748
Synonyms MF1; RAD2; FEN-1
Reactivity Human, Mouse, Rat
Application WB, IHC
Recommended dilution WB: 1:1000-1:5000
IHC: 1:50-1:200
Calculated MW 43 kDa
Observed MW 43 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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