Phospho-VAV1 (Tyr174) Rabbit pAb - diagbio | 戴格生物

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Phospho-VAV1 (Tyr174) Rabbit pAb

db24564

年底大促

Datasheet

Product Name : Phospho-VAV1 (Tyr174) Rabbit pAb

Cat.No.: db24564

Synonyms : VAV

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr174 of human VAV1
Gene ID 7409
Swiss Prot P15498
Synonyms VAV
Reactivity Human
Application WB, ICC/IF, FC
Recommended dilution WB: 1:1000
ICC/IF: 1:100
FC: 1:20
Calculated MW 98 kDa
Observed MW 98 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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