RAP1GAP Rabbit pAb - diagbio | 戴格生物

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RAP1GAP Rabbit pAb

db2554

年底大促

Datasheet

Product Name : RAP1GAP Rabbit pAb

Cat.No.: db2554

Synonyms : RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Immunogen A synthetic peptide of human RAP1GAP
Gene ID 5909
Swiss Prot P47736
Synonyms RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
Reactivity Human, Mouse, Rat
Application WB, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
ICC/IF: 1:20-1:50
FC: 1:20
IP: 1:20
Calculated MW 73 kDa
Observed MW 95 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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