Product Name :
Huntingtin Rabbit pAb
Cat.No.:
db2592
Synonyms :
HD; IT15; LOMARS
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
-
Background
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]
-
Immunogen
A synthetic peptide of human Huntingtin
-
Gene ID
3064
-
Swiss Prot
P42858
-
Synonyms
HD; IT15; LOMARS
-
Reactivity
Human, Mouse, Rat
-
Application
WB, IHC, ICC/IF, FC
-
Recommended dilution
WB: 1:2000
IHC: 1:20
ICC/IF: 1:20
FC: 1:20
-
Calculated MW
348 kDa
-
Observed MW
348 kDa
-
Host species
Rabbit
-
Clonality
Polyclonal
-
Isotype
IgG
-
Purity
Affinity Purification
-
Conjugation
Un-conjugated
-
Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
-
Package
Price (RMB)
-
20μL
598
-
50μL
998
-
100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
浙公网安备 33010602008812号