MTH1 Rabbit pAb - diagbio | 戴格生物

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MTH1 Rabbit pAb

db2642

年底大促

Datasheet

Product Name : MTH1 Rabbit pAb

Cat.No.: db2642

Synonyms : MTH1

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
Immunogen Recombinant protein of human MTH1
Gene ID 4521
Swiss Prot P36639
Synonyms MTH1
Reactivity Human
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:1000
IHC: 1:20
ICC/IF: 1:50
FC: 1:20
Calculated MW 23 kDa
Observed MW 18 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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