BRCC36 Rabbit pAb - diagbio | 戴格生物

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BRCC36 Rabbit pAb

db2714

年底大促

Datasheet

Product Name : BRCC36 Rabbit pAb

Cat.No.: db2714

Synonyms : C6.1A; BRCC36; CXorf53

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Immunogen A synthetic peptide of human BRCC36
Gene ID 79184
Swiss Prot P46736
Synonyms C6.1A; BRCC36; CXorf53
Reactivity Human, Mouse, Rat
Application WB, FC, IP
Recommended dilution WB: 1:2000-1:10000
FC: 1:20-1:100
IP: 1:20-1:50
Calculated MW 36 kDa
Observed MW 36 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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