IREB2 Rabbit pAb - diagbio | 戴格生物

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IREB2 Rabbit pAb

db2936

年底大促

Datasheet

Product Name : IREB2 Rabbit pAb

Cat.No.: db2936

Synonyms : ACO3; IRP2; IRP2AD; IRE-BP2; IRE-BP 2

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Immunogen Recombinant protein of human IREB2
Gene ID 3658
Swiss Prot P48200
Synonyms ACO3; IRP2; IRP2AD; IRE-BP2; IRE-BP 2
Reactivity Human, Mouse, Rat
Application WB, FC
Recommended dilution WB: 1:1000
FC: 1:20
Calculated MW 105 kDa
Observed MW 105 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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