G protein alpha 13 Rabbit pAb - diagbio | 戴格生物

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G protein alpha 13 Rabbit pAb

db2949

年底大促

Datasheet

Product Name : G protein alpha 13 Rabbit pAb

Cat.No.: db2949

Synonyms : G13

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).
Immunogen A synthetic peptide of human G protein alpha 13
Gene ID 10672
Swiss Prot Q14344
Synonyms G13
Reactivity Human, Mouse, Rat
Application WB, IHC
Recommended dilution WB: 1:1000-1:5000
IHC: 1:200
Calculated MW 44 kDa
Observed MW 44 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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