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Conjugation/Formulation：Un-conjugated
- Background This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
- Immunogen Recombinant protein of human PEG10
-
Gene ID
23089
-
Swiss Prot
Q86TG7
- Synonyms EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1
- Reactivity Human
- Application WB, IHC, ICC/IF, FC, IP
-
Recommended dilution
WB: 1:1000
IHC: 1:50
ICC/IF: 1:50
FC: 1:50
IP: 1:20 - Calculated MW 80 kDa
- Observed MW 100,55 kDa
- Host species Rabbit
- Clonality Polyclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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订购信息
- Package Price (RMB)
- 20μL 598
- 50μL 998
- 100μL 1798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
