Cullin 2 Rabbit pAb - diagbio | 戴格生物

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Cullin 2 Rabbit pAb

db4645

年底大促

Datasheet

Product Name : Cullin 2 Rabbit pAb

Cat.No.: db4645

Synonyms : CUL2; Cullin-2

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Immunogen A synthetic peptide of human Cullin 2
Gene ID 8453
Swiss Prot Q13617
Synonyms CUL2; Cullin-2
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
IHC: 1:20
ICC/IF: 1:20
FC: 1:20
IP: 1:20
Calculated MW 87 kDa
Observed MW 87 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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