KRIT1 Rabbit pAb - diagbio | 戴格生物

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KRIT1 Rabbit pAb

db5635

年底大促

Datasheet

Product Name : KRIT1 Rabbit pAb

Cat.No.: db5635

Synonyms : CAM; CCM1

Application：

Reactivity : Human, Mouse

Host species : Rabbit

Un-conjugated

Background This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Immunogen Recombinant protein of human KRIT1
Gene ID 889
Swiss Prot O00522
Synonyms CAM; CCM1
Reactivity Human, Mouse
Application WB, IHC, ICC/IF
Recommended dilution WB: 1:1000
IHC: 1:20
ICC/IF: 1:20
Calculated MW 84 kDa
Observed MW 84 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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