HIKESHI Rabbit pAb - diagbio | 戴格生物

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HIKESHI Rabbit pAb

db5865

年底大促

Datasheet

Product Name : HIKESHI Rabbit pAb

Cat.No.: db5865

Synonyms : HLD13; L7RN6; OPI10; HSPC138; HSPC179; C11orf73

Application：

Reactivity : Human, Mouse

Host species : Rabbit

Un-conjugated

Background This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
Immunogen A synthetic peptide of human HIKESHI
Gene ID 51501
Swiss Prot Q53FT3
Synonyms HLD13; L7RN6; OPI10; HSPC138; HSPC179; C11orf73
Reactivity Human, Mouse
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:1000
IHC: 1:20
ICC/IF: 1:100
IP: 1:20
Calculated MW 22 kDa
Observed MW 22 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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