Aurora A (2E3) Mouse mAb (PBS Only) - diagbio | 戴格生物

产品中心 Products Center

您当前的位置：

Aurora A (2E3) Mouse mAb (PBS Only)

db6083-PBS

Datasheet

Product Name : Aurora A (2E3) Mouse mAb (PBS Only)

Cat.No.: db6083-PBS

Synonyms : AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47

Application：

WB
ICC/IF

Reactivity : Human, Monkey

Host species : Mouse

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Immunogen Purified recombinant human Aurora Kinase A protein fragments expressed in E.coli
Gene ID 6790
Swiss Prot O14965
Synonyms AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47
Reactivity Human, Monkey
Application WB, ICC/IF
Calculated MW 46 kDa
Observed MW 46 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 2E3-C10-C11-G6
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of Aurora Kinase A in SW480 and COS7 lysates using Aurora Kinase A antibody.
Immunocytochemistry analysis of Aurora A (2E3) in HeLa using Aurora Kinase A antibody.
Immunofluorescence analysis of Aurora A (2E3) in Hela cells using Aurora Kinase A antibody(green) and Histone H3.1 (Phospho-Ser1) antibody (red),and DAPI (blue)

订购信息

Package Price (RMB)
可询价
货期：现货