CDK4 (3F9) Mouse mAb (PBS Only) - diagbio | 戴格生物

产品中心 Products Center

您当前的位置：

CDK4 (3F9) Mouse mAb (PBS Only)

db6087-PBS

Datasheet

Product Name : CDK4 (3F9) Mouse mAb (PBS Only)

Cat.No.: db6087-PBS

Synonyms : CMM3; PSK-J3

Application：

Reactivity : Human, Mouse, Rat

Host species : Mouse

Un-conjugated PBS Only

Background Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Immunogen Purified recombinant human CDK4 protein fragments expressed in E.coli
Gene ID 1019
Swiss Prot P11802
Synonyms CMM3; PSK-J3
Reactivity Human, Mouse, Rat
Application WB
Calculated MW 34 kDa
Observed MW 34 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 3F9-B12-C8
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of CDK4 in Hela, Lncap and F9 lysates using CDK4 antibody.
Western blot analysis of CDK4 (3F9) in Hela, C6 and F9 lysates using CDK4 antibody.

订购信息