TAK1 (3G1) Mouse mAb (PBS Only) - diagbio | 戴格生物

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TAK1 (3G1) Mouse mAb (PBS Only)

db6118-PBS

Datasheet

Product Name : TAK1 (3G1) Mouse mAb (PBS Only)

Cat.No.: db6118-PBS

Synonyms : CSCF; FMD2; TAK1; MEKK7; TGF1a

Application：

Reactivity : Human, Mouse, Rat, Monkey

Host species : Mouse

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
Immunogen Purified recombinant human TAK1 protein fragments expressed in E.coli
Gene ID 6885
Swiss Prot O43318
Synonyms CSCF; FMD2; TAK1; MEKK7; TGF1a
Reactivity Human, Mouse, Rat, Monkey
Application WB
Calculated MW 67 kDa
Observed MW 67,78 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 3G1-C4-E10
Isotype IgG2b
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of TAK1 in K562, Hela, MCF-7, COS7, 3T3 and C6 lysates using TAK1 antibody.

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货期：现货