STAT1 (6C2) Mouse mAb - diagbio | 戴格生物

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STAT1 (6C2) Mouse mAb

db6216

Product Name : STAT1 (6C2) Mouse mAb

Cat.No.: db6216

Synonyms : STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84

Application：

Reactivity : Human, Monkey

Host species : Mouse

Conjugation/Formulation：Un-conjugated

Un-conjugated

Background Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),cytokine KITLG/SCF and other cytokines and other growth factors.Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors,signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2.The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor,that enters the nucleus.ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG),which drive the cell in an antiviral state.In response to type II IFN (IFN-gamma),STAT1 is tyrosine- and serine-phosphorylated.It then forms a homodimer termed IFN-gamma-activated factor (GAF),migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes,inducing a cellular antiviral state.Becomes activated in response to KITLG/SCF and KIT signaling.May mediate cellular responses to activated FGFR1,FGFR2,FGFR3 and FGFR4.
Immunogen Purified recombinant human STAT1 protein fragments expressed in E.coli
Gene ID 6772
Swiss Prot P42224
Synonyms STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
Reactivity Human, Monkey
Application WB, IP
Recommended dilution WB: 1:500-1:1000
IP: 1:20
Calculated MW 87 kDa
Observed MW 91 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 6C2-F7-D12
Isotype IgG2a
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% Glycerol(pH 7.3), 0.02% sodium azide and 0.5% BSA . Stable for 12 months from date of receipt.

Western blot analysis of STAT1 in Hela, MCF-7, COS7, SW480 and A549 lysates using STAT1 antibody.
Immunoprecipitation analysis of STAT1 (6C2) in Hela lysates using STAT1 antibody.

订购信息

Package Price (RMB)
50μL 1398
100μL 2398
货期：现货