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EGFR (1A11) Mouse mAb
db6225
Datasheet
Conjugation/Formulation：Un-conjugated
- Background Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
- Immunogen Purified recombinant human EGFR protein fragments expressed in E.coli
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Gene ID
1956
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Swiss Prot
P00533
- Synonyms ERBB;HER1;mENA;ERBB1;PIG61
- Reactivity Human
- Application WB, IP
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Recommended dilution
WB: 1:500-1:1000
IP: 1:20 - Calculated MW 134 kDa
- Observed MW 175 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 1A11-G9-1E9
- Isotype IgG1
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% Glycerol(pH 7.3), 0.02% sodium azide and 0.5% BSA . Stable for 12 months from date of receipt.
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Western blot analysis of EGFR in A549 lysates using EGFR antibody. -
Immunoprecipitation analysis of EGFR (1A11) in Hela lysates using EGFR antibody.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
