Product Name : Lamin A/C Mouse mAb (PBS Only)
Cat.No.: db6230-PBS
Synonyms : FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
Reactivity : Human, Mouse, Rat
Host species : Mouse
Conjugation/Formulation：PBS Only
- Background Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the innernuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact withchromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role innuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal developmentof peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required forosteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping tomaintain the volume and strength of skeletal muscle and bone Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and prematuresenescence.
- Immunogen Purified recombinant human LMNA protein fragments expressed in E.coli
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Gene ID
4000
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Swiss Prot
P02545
- Synonyms FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
- Reactivity Human, Mouse, Rat
- Application WB
- Calculated MW 74 kDa
- Observed MW 74 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 3D6-F4-B7
- Isotype IgG2a
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of Lamin A in K562, C6, 3T3 and Hela lysates using Lamin A antibody.
- Package Price (RMB)
- 可询价
- 货期：现货
