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HDAC2 (2D9) Mouse mAb (PBS Only)
db6345-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
- Immunogen Purified recombinant human HDAC2 protein fragments expressed in E.coli
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Gene ID
3066
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Swiss Prot
Q92769
- Synonyms HDAC2; Histone deacetylase 2; HD2
- Reactivity Human, Mouse, Rat, Monkey
- Application WB, ICC/IF
- Calculated MW 55 kDa
- Observed MW 60 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 2D9-F6-G7
- Isotype IgG2b
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of HDAC2 in THP-1, SH-SY5Y, K562, COS7, C6, 3T3 and Hela lysates using HDAC2 antibody.
订购信息
- Package Price (RMB)
- 可询价
- 货期：现货
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For research use only. Not intended for diagnostic.
