PYK2 (4B4) Mouse mAb (PBS Only) - diagbio | 戴格生物

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PYK2 (4B4) Mouse mAb (PBS Only)

db6398-PBS

Datasheet

Product Name : PYK2 (4B4) Mouse mAb (PBS Only)

Cat.No.: db6398-PBS

Synonyms : PKB; PTK; CAKB; FAK2; FRNK; PTK2B

Application：

WB
IHC-P

Reactivity : Human

Host species : Mouse

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background PYK2/ PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Immunogen Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli
Gene ID 2185
Swiss Prot Q14289
Synonyms PKB; PTK; CAKB; FAK2; FRNK; PTK2B
Reactivity Human
Application WB, IHC-P
Calculated MW 116 kDa
Observed MW 116 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 4B4-D0-F3
Isotype IgG2a
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of Pyk2 in A549, Ramos, Jurkat, THP-1 and Raji lysates using Pyk2 antibody.
Immunohistochemistry analysis of paraffin-embedded Human Tonsil tissues using PYK2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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