Survivin (8B9) Mouse mAb (PBS Only) - diagbio | 戴格生物

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Survivin (8B9) Mouse mAb (PBS Only)

db6518-PBS

Product Name : Survivin (8B9) Mouse mAb (PBS Only)

Cat.No.: db6518-PBS

Synonyms : BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin

Application：

WB
IHC-P

Reactivity : Human, Rat

Host species : Mouse

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed/9859993, PubMed/21364656, PubMed/20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed/16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed/20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed/20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed/18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed/9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed/20826784). May play a role in neoplasia (PubMed/10626797). Inhibitor of CASP3 and CASP7 (PubMed/21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed/12773388, PubMed/16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed/10626797).
Immunogen Recombinant Protein of Survivin
Gene ID 332
Swiss Prot O15392
Synonyms BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
Reactivity Human, Rat
Application WB, IHC-P
Calculated MW 16 kDa
Observed MW 16 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 8B9-6G6-1G4
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of Survivin in TF1, HL6 lysates using Survivin (8B9) antibody.
Immunohistochemistry analysis of paraffin-embedded Human colon caricnoma using Survivin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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货期：现货