TGF beta 1 (7C9) Mouse mAb (PBS Only) - diagbio | 戴格生物

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TGF beta 1 (7C9) Mouse mAb (PBS Only)

db6541-PBS

Datasheet

Product Name : TGF beta 1 (7C9) Mouse mAb (PBS Only)

Cat.No.: db6541-PBS

Synonyms : TGF beta 1; TGFB; CED; LAP

Application：

IHC-P

Reactivity : Mouse, Rat

Host species : Mouse

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts . Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed/25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed/25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed/25893292).
Immunogen Synthetic peptide conjugated to KLH
Gene ID 7040
Swiss Prot P01137
Synonyms TGF beta 1; TGFB; CED; LAP
Reactivity Mouse, Rat
Application IHC-P
Host species Mouse
Clonality Monoclonal
Clonality No. 7C9-8D7-5G1
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Immunohistochemistry analysis of paraffin-embedded mouse Lung Tissue using TGF beta 1 (7C9) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Immunohistochemical analysis of paraffin-embedded Human tonsils using TGF beta 1 (7C9) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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货期：现货