PTEN (7H2) Mouse mAb (PBS Only) - diagbio | 戴格生物

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PTEN (7H2) Mouse mAb (PBS Only)

db6563-PBS

Datasheet

Product Name : PTEN (7H2) Mouse mAb (PBS Only)

Cat.No.: db6563-PBS

Synonyms : BZS;MHAM;MMAC1;TEP1;phosphatase and tensin homolog

Application：

IHC-P

Reactivity : Human

Host species : Mouse

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed/26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
Immunogen Synthetic peptide conjugated to KLH
Gene ID 5728
Swiss Prot P60484
Synonyms BZS;MHAM;MMAC1;TEP1;phosphatase and tensin homolog
Reactivity Human
Application IHC-P
Calculated MW 54 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 7H2-6G9-6H5
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using PTEN (7H2) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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货期：现货