MRP2 Rabbit pAb - diagbio | 戴格生物

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MRP2 Rabbit pAb

db7318

年底大促

Datasheet

Product Name : MRP2 Rabbit pAb

Cat.No.: db7318

Synonyms : DJS; MRP2; cMRP; ABC30; CMOAT

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human MRP2
Gene ID 1244
Swiss Prot Q92887
Synonyms DJS; MRP2; cMRP; ABC30; CMOAT
Reactivity Human
Application WB, ICC/IF, FC
Recommended dilution WB: 1:1000
ICC/IF: 1:50
FC: 1:20-1:100
Calculated MW 174 kDa
Observed MW >200 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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