C14orf169/NO66 Rabbit pAb - diagbio | 戴格生物

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C14orf169/NO66 Rabbit pAb

db753

年底大促

Datasheet

Product Name : C14orf169/NO66 Rabbit pAb

Cat.No.: db753

Synonyms : ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated Un-conjugated Un-conjugated

Background Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Immunogen Recombinant protein of human C14orf169/NO66
Gene ID 79697
Swiss Prot Q9H6W3
Synonyms ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
Reactivity Human, Mouse, Rat
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 71 kDa
Observed MW 71 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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