OLFM2 Rabbit pAb - diagbio | 戴格生物

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OLFM2 Rabbit pAb

db7801

年底大促

Datasheet

Product Name : OLFM2 Rabbit pAb

Cat.No.: db7801

Synonyms : NOE2; OlfC; NOELIN2; NOELIN2_V1

Application：

Reactivity : Human, Mouse

Host species : Rabbit

Un-conjugated

Background Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).
Immunogen A synthetic peptide of human OLFM2
Gene ID 93145
Swiss Prot O95897
Synonyms NOE2; OlfC; NOELIN2; NOELIN2_V1
Reactivity Human, Mouse
Application WB, IHC, ICC/IF
Recommended dilution WB: 1:1000
IHC: 1:50
ICC/IF: 1:50
Calculated MW 51 kDa
Observed MW 49 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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