Product Name :
BRSK1 Rabbit pAb
Cat.No.:
db782
Synonyms :
hSAD1
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
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Background
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
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Immunogen
Recombinant protein of human BRSK1
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Gene ID
84446
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Swiss Prot
Q8TDC3
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Synonyms
hSAD1
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Reactivity
Human, Mouse, Rat
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Application
WB, ICC/IF
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Recommended dilution
WB: 1:1000
ICC/IF: 1:20
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Calculated MW
85 kDa
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Observed MW
85 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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