ERCC1 Rabbit pAb - diagbio | 戴格生物

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ERCC1 Rabbit pAb

db7907

年底大促

Datasheet

Product Name : ERCC1 Rabbit pAb

Cat.No.: db7907

Synonyms : UV20; COFS4; RAD10

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
Immunogen A synthetic peptide of human ERCC1
Gene ID 2067
Swiss Prot P07992
Synonyms UV20; COFS4; RAD10
Reactivity Human
Application WB, FC
Recommended dilution WB: 1:1000
FC: 1:20
Calculated MW 33 kDa
Observed MW 39 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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