RPE65 Rabbit pAb - diagbio | 戴格生物

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RPE65 Rabbit pAb

db8646

年底大促

Datasheet

Product Name : RPE65 Rabbit pAb

Cat.No.: db8646

Synonyms : p63; BCO3; LCA2; RP20; rd12; mRPE65; sRPE65

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated

Background The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
Immunogen A synthetic peptide of human RPE65
Gene ID 6121
Swiss Prot Q16518
Synonyms p63; BCO3; LCA2; RP20; rd12; mRPE65; sRPE65
Reactivity Human, Mouse, Rat
Application WB, IHC, IP
Recommended dilution WB: 1:1000
IHC: 1:200
IP: 1:20
Calculated MW 61 kDa
Observed MW 65 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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