DAP12 Rabbit pAb - diagbio | 戴格生物

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DAP12 Rabbit pAb

db8668

年底大促

Datasheet

Product Name : DAP12 Rabbit pAb

Cat.No.: db8668

Synonyms : DAP12; KARAP; PLOSL

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated

Background This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Immunogen A synthetic peptide of human DAP12
Gene ID 7305
Swiss Prot O43914
Synonyms DAP12; KARAP; PLOSL
Reactivity Human
Application WB, ICC/IF, FC
Recommended dilution WB: 1:1000
ICC/IF: 1:50
FC: 1:20
Calculated MW 12 kDa
Observed MW 12 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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